1 Title Age - dependent effect of hearing loss on cortical inhibitory synapse 2 function
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Title Age-dependent effect of hearing loss on cortical inhibitory synapse 2 function 3 4 Authors Anne E. Takesian, Vibhakar C. Kotak, Dan H. Sanes 5 6 Author Affiliation Center for Neural Science 7 Department of Biology 8 New York University 9 4 Washington Place, Rm. 809 10 New York, NY 10003 11 12 Running Head Early hearing loss impacts cortical inhibition 13 14 Contact Information 15 Anne E. Takesian 16 Children’s Hospital Boston 17 Harvard Medical School 18 Center for Life Sciences Building 19 Room 13039 20 3 Blackfan Circle 21 Boston, MA 02115 22 Phone: 617-699-2045 23 Fax: 617-919-2380 24 Email: [email protected] 25 26 Figures 5 27 Tables 1 28 Pages 35 (including cover page, references, and figure legends) 29 30 Words 31 Abstract 207 32 Introduction 562 33 Methods 1495 34 Results 1444 35 Discussion 1757 36 37 38 39 Articles in PresS. J Neurophysiol (November 16, 2011). doi:10.1152/jn.00515.2011
منابع مشابه
Age-dependent effect of hearing loss on cortical inhibitory synapse function.
The developmental plasticity of excitatory synapses is well established, particularly as a function of age. If similar principles apply to inhibitory synapses, then we would expect manipulations during juvenile development to produce a greater effect and experience-dependent changes to persist into adulthood. In this study, we first characterized the maturation of cortical inhibitory synapse fu...
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Inhibitory synapse dysfunction may contribute to many developmental brain disorders, including the secondary consequences of sensory deprivation. In fact, developmental hearing loss leads to a profound reduction in the strength of inhibitory postsynaptic currents (IPSCs) in the auditory cortex, and this deficit persists into adulthood. This finding is consistent with the general theory that the...
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تاریخ انتشار 2011